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What is BHA™?

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  • BHA™ is a physically stabilised form of Hyaluronic Acid (HA).

  • Stabilisation is achieved through a patented microwave-based technology that links carboxyl and amine groups (requiring additional NH groups, provided by proline).

  • This modification is physical, not chemical, avoiding toxic organic solvents or reagents.

  • Result: Longer-lasting HA with higher resistance to enzymatic and chemical degradation.​

Key Properties

  • Molecular weight: 2.8–3.6 MDa.

  • Purity: Achieved via advanced filtration processes.

  • Biocompatibility: Especially important for soft tissue, where immune activity is higher.

  • Stability: Microwave stabilisation ensures prolonged effect in soft tissues (which degrade HA faster than joints).

Role in Soft Tissue Injuries

Physiopathology of Ligament Sprains

  1. Acute inflammatory/bleeding phase (0–72h):

    • Clot formation; fibrin + platelets release growth factors.

  2. Proliferative phase:

    • Fibroblast proliferation; ECM and collagen type III deposition.

    • Tissue forms disorganised scar-like matrix.

  3. Remodelling phase:

    • Weeks to months: collagen matures, aligning into more normal ligament structure.

    • However, matrix remains weaker and structurally different from native ligament.

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Mechanism of Action of BHA™

In Ligament Sprains

  • Acute phase:

    • BHA™ combines with fibrin at injury site → BHA–fibrin complex.

    • Creates hydrodynamic cushion (scaffold effect).

    • Reduces inflammation and promotes cell proliferation.

  • Proliferative & Remodeling phases:

    • Supports better collagen alignment.

    • Reduces scar tissue formation.

    • Improves lubrication, decreases adhesions, speeds up recovery.

Benefits in ligaments:

  • Better healing quality.

  • Stronger tensile strength.

  • Earlier return to function.

In Tendon Injuries (Chronic/Tendinopathy)

  • Tendon anatomy: Collagen fibres in parallel bundles + ECM rich in HA and proteoglycans.

  • Injury: Disorganisation of fibres and ECM → impaired gliding, reduced strength & mobility.

  • Healing process:

    • Proliferative stage → fibroblasts deposit ECM and collagen type III (weaker, disorganised).

    • Maturation stage → gradual replacement with type I collagen.

Role of HA in healing:

  • Maintains healthy ECM.

  • Improves lubrication and cell nutrition.

  • Stimulates collagen synthesis.

  • Aids conversion of collagen III → collagen I.

BHA™ effects in tendons:

  • Supplements HA at injury site.

  • Improves ECM quality & lubrication.

  • Realigns collagen fibres.

  • Reduces adhesions and scar tissue.

  • Accelerates recovery, reduces pain, restores strength and mobility.

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Result

  • BHA™ = microwave-stabilised, biocompatible Hyaluronic Acid.

  • Provides a long-lasting, safe alternative for treating soft tissue injuries.

  • Helps patients with ligament and tendon injuries recover faster, better, and with less pain.

  • Reduces risk of recurrence by improving healing quality and limiting scar tissue.

  • Localised, targeted therapy that complements or improves upon standard care.

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